Blar i forfatter "Krasnov, Aleksei"

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    • Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes 

      Wessel, Øystein; Krasnov, Aleksei; Timmerhaus, Gerrit; Rimstad, Espen; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-16)
      Salmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle ...

    • The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense 

      Gjessing, Mona Cecilie; Krasnov, Aleksei; Timmerhaus, Gerrit; Brun, Svante; Afanasyev, Sergey; Dale, Ole Bendik; Dahle, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-04)
      The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. ...

    • The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense 

      Gjessing, Mona Cecilie; Krasnov, Aleksei; Timmerhaus, Gerrit; Brun, Svante; Afanasyev, Sergey; Dale, Ole Bendik; Dahle, Maria K (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-04)
      The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. ...

    • CpG- and LPS-activated MAPK signaling in in vitro cultured salmon (Salmo salar) mononuclear phagocytes 

      Iliev, Dimitri Borisov; Hansen, Tom Egil; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The Mitogen-activated protein kinases (MAPK) are involved in transmitting intracellular signals downstream of diverse cell surface receptors and mediate the response to ligands such as growth factors, hormones and cytokines. In addition, MAPK are critically involved in the innate immune response to pathogen-derived substances, commonly referred to as pathogen-associated molecular patterns (PAMPs), ...

    • CpGs Induce Differentiation of Atlantic Salmon Mononuclear Phagocytes Into Cells With Dendritic Morphology and a Proinflammatory Transcriptional Profile but an Exhausted Allostimulatory Activity 

      Iliev, Dimitar Borisov; Lagos, Leidy; Thim, Hanna Leena; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-13)
      Due to their ability to present foreign antigens and prime naïve T cells, macrophages, and dendritic cells (DCs) are referred to as professional antigen-presenting cells (APCs). Although activated macrophages may function as APCs, these cells are particularly effective at directly engaging pathogens through phagocytosis, and production of antimicrobial compounds. On the other hand, DCs possess superb ...

    • Development of Atlantic Salmon (Salmo salar L.) Under Hypoxic Conditions Induced Sustained Changes in Expression of Immune Genes and Reduced Resistance to Moritella viscosa 

      Krasnov, Aleksei; Burgerhout, Erik; Johnsen, Hanne; Tveiten, Helge; Bakke, Anne Flore; Lund, Hege; Afanasyev, Sergey; Rebl, Alexander; Johansen, Lill-Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      Atlantic salmon is characterized with high sensitivity to low dissolved oxygen (DO) levels. Hypoxia can affect diverse biological processes with consequences that can be manifested immediately or with delay. Effects of hypoxia on the immune system and the resistance to a bacterial pathogen were investigated. Two groups were reared at, respectively, normal (NO, 80–100%) and low (LO, 60%) levels of ...

    • IPNV with high and low virulence: host immune responses and viral mutations during infection 

      Skjesol, Astrid; SkjÆveland, ingrid; Elnæs, Marianne; Timmerhaus, Gerrit Frantz; Fredriksen, Børge Nilsen; Jørgensen, Sven Martin; Krasnov, Aleksei; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Infectious pancreatic necrosis virus (IPNV) is an aquatic member of the Birnaviridae family that causes widespread disease in salmonids. IPNV is represented by multiple strains with markedly different virulence. Comparison of isolates reveals hyper variable regions (HVR), which are presumably associated with pathogenicity. However little is known about the rates and modes of sequence divergence and ...

    • Morphology, Transcriptomics and In Vitro Model of Skin from Polar Cod (Boreogadus Saida) and Atlantic Cod (Gadus Morhua) 

      Ytteborg, Elisabeth; Hansen, Øyvind Johannes; Høst, Vibeke; Afanasyev, Sergey; Vieweg, Ireen; Nahrgang, Jasmine; Krasnov, Aleksei (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
      Fish skin is a multifunctional barrier tissue with high regeneration capacity that interacts with the surrounding environment and provides protection. Functional importance, high complexity and activity make skin an attractive tissue for studying the effects of environmental challenges and chemical stressors in fish. The aim of this work was to characterize skin from polar cod (<i>Boreogadus saida</i>) ...

    • Multifaktorielle sykdommer i norsk lakseoppdrett. Sluttrapport 

      Johansen, Lill-Heidi; Bang-Jensen, Berit; Jansen, Mona Dverdal; Taksdal, Torunn; Krasnov, Aleksei (Research report; Forskningsrapport, 2015-07-02)
      Prosjektet «Multifaktorielle sykdommer i norsk lakseoppdrett» er utført i et samarbeid mellom Nofima, Veterinærinstituttet, AquaGen AS og Patogen AS. Hovedmålet for prosjektet var å øke kunnskapen om utviklingen av multifaktorielle sykdommer ved å vurdere effekten av ulike variabler og deres interaksjon. Effekten av ulike variabler (genetisk resistens mot IPN, IPNV bærer status, IPNV reaktivering ...

    • Nanofiltration of intake water in RAS: Effect on fish performance, health and welfare 

      Ytrestøyl, Trine; Sveen, Lene; Krasnov, Aleksei; Dalum, Alf Seljenes; Kolarevic, Jelena (Research report; Forskningsrapport, 2022)
      The experiment tested the effect of nanomembrane filtration in RAS on the salmon's physiology, welfare and growth. A specially designed membrane was used to remove sulphate from seawater and to adjust salinity from 32 to 12 ‰. A RAS where salinity was adjusted to 12 ‰ by mixing raw seawater and freshwater was used as control. The fish were kept in the two systems for 10 weeks before being ...

    • Transcriptome analyses of Atlantic salmon muscle genes induced by a DNA vaccine against salmonid alphavirus, the causative agent of salmon pancreas disease (PD) 

      Sobhkhez, Mehrdad; Krasnov, Aleksei; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Salmonid alphavirus (SAV) is the causative agent of pancreas disease (PD) in farmed Atlantic salmon. A previous study showed that vaccination of pre-smolt salmon with a plasmid encoding the structural polypeptide of SAV gave protection against infection and development of PD accompanied by production of antibodies against the virus. In the present work we analyzed transcript responses in the muscle ...

    • Transcriptome analysis of plasmid-induced genes sheds light on the role of type I IFN as adjuvant in DNA vaccine against infectious salmon anemia virus 

      Sobhkhez, Mehrdad; Krasnov, Aleksei; Chang, Chia Jung; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-21)
      A previous study showed that a plasmid expressing IFNa (pIFNa) strongly enhanced protection and antibody production of a DNA vaccine against infectious salmon anemia virus (ISAV) in Atlantic salmon. The vaccine consisted of a plasmid (pHE) expressing the virus hemagglutinin-esterase as an antigen. To increase the understanding of the adjuvant effect of pIFNa, we here compared transcriptome responses ...